Cargando…

Unfolding the HIV-1 reverse transcriptase RNase H domain – how to lose a molecular tug-of-war

Formation of the mature HIV-1 reverse transcriptase (RT) p66/p51 heterodimer requires subunit-specific processing of the p66/p66′ homodimer precursor. Since the ribonuclease H (RH) domain contains an occult cleavage site located near its center, cleavage must occur either prior to folding or subsequ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Xunhai, Pedersen, Lars C., Gabel, Scott A., Mueller, Geoffrey A., DeRose, Eugene F., London, Robert E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770237/ https://www.ncbi.nlm.nih.gov/pubmed/26773054 http://dx.doi.org/10.1093/nar/gkv1538

Ejemplares similares

Coordination between the polymerase and RNase H activity of HIV-1 reverse transcriptase
por: Figiel, Małgorzata, et al.
Publicado: (2017)

Altered error specificity of RNase H-deficient HIV-1 reverse transcriptases during DNA-dependent DNA synthesis
por: Álvarez, Mar, et al.
Publicado: (2013)

Transitions in DNA polymerase β μs-ms dynamics related to substrate binding and catalysis
por: DeRose, Eugene F, et al.
Publicado: (2018)

Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase: antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors
por: Schneider, Anna, et al.
Publicado: (2016)

Selective unfolding of one Ribonuclease H domain of HIV reverse transcriptase is linked to homodimer formation
por: Zheng, Xunhai, et al.
Publicado: (2014)

The mechano-chemistry of a monomeric reverse transcriptase
por: Malik, Omri, et al.
Publicado: (2017)

Molecular cloning and characterization of the human RNase κ, an ortholog of Cc RNase
por: Economopoulou, Marie-angela I., et al.
Publicado: (2007)

Pausing kinetics dominates strand-displacement polymerization by reverse transcriptase
por: Malik, Omri, et al.
Publicado: (2017)

Limited reverse transcriptase activity of phi29 DNA polymerase
por: Krzywkowski, Tomasz, et al.
Publicado: (2018)

Base modifications affecting RNA polymerase and reverse transcriptase fidelity
por: Potapov, Vladimir, et al.
Publicado: (2018)

Yeast mitochondrial RNase P, RNase Z and the RNA degradosome are part of a stable supercomplex
por: Daoud, Rachid, et al.
Publicado: (2012)

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase
por: Jackson, Lynnette N, et al.
Publicado: (2019)

RNase MRP RNA and RNase P activity in plants are associated with a Pop1p containing complex
por: Krehan, Mario, et al.
Publicado: (2012)

E. coli RNase I exhibits a strong Ca(2+)-dependent inherent double-stranded RNase activity
por: Grünberg, Sebastian, et al.
Publicado: (2021)

AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP
por: Hartl, Maximilian J., et al.
Publicado: (2008)

A reverse transcriptase-related protein mediates phage resistance and polymerizes untemplated DNA in vitro
por: Wang, Chen, et al.
Publicado: (2011)

Mechanism of allosteric inhibition of HIV-1 reverse transcriptase revealed by single-molecule and ensemble fluorescence
por: Schauer, Grant D., et al.
Publicado: (2014)

The active site residue Valine 867 in human telomerase reverse transcriptase influences nucleotide incorporation and fidelity
por: Drosopoulos, William C., et al.
Publicado: (2007)

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase
por: Ndongwe, Tanyaradzwa P., et al.
Publicado: (2012)

Direct tracking of reverse-transcriptase speed and template sensitivity: implications for sequencing and analysis of long RNA molecules
por: Guo, Li-Tao, et al.
Publicado: (2022)

Heterodimerization of the human RNase P/MRP subunits Rpp20 and Rpp25 is a prerequisite for interaction with the P3 arm of RNase MRP RNA
por: Hands-Taylor, Katherine L. D., et al.
Publicado: (2010)

Sequence-specific cleavage of dsRNA by Mini-III RNase
por: Głów, Dawid, et al.
Publicado: (2015)

RNase H sequence preferences influence antisense oligonucleotide efficiency
por: Kiełpiński, Łukasz J., et al.
Publicado: (2017)

Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids
por: Dash, Chandravanu, et al.
Publicado: (2008)

Arm-specific cleavage and mutation during reverse transcription of 2΄,5΄-branched RNA by Moloney murine leukemia virus reverse transcriptase
por: Döring, Jessica, et al.
Publicado: (2017)

Degradation of nanoRNA is performed by multiple redundant RNases in Bacillus subtilis
por: Fang, Ming, et al.
Publicado: (2009)

RNase L restricts the mobility of engineered retrotransposons in cultured human cells
por: Zhang, Ao, et al.
Publicado: (2014)

Structural insights into catalysis and dimerization enhanced exonuclease activity of RNase J
por: Zhao, Ye, et al.
Publicado: (2015)

Chaperone activation of the hepadnaviral reverse transcriptase for template RNA binding is established by the Hsp70 and stimulated by the Hsp90 system
por: Stahl, Michael, et al.
Publicado: (2007)

Novel mutations in Moloney Murine Leukemia Virus reverse transcriptase increase thermostability through tighter binding to template-primer
por: Arezi, Bahram, et al.
Publicado: (2009)

Effects of HIV-1 reverse transcriptase connection subdomain mutations on polypurine tract removal and initiation of (+)-strand DNA synthesis
por: Betancor, Gilberto, et al.
Publicado: (2015)

Reverse transcriptases can clamp together nucleic acids strands with two complementary bases at their 3′-termini for initiating DNA synthesis
por: Oz-Gleenberg, Iris, et al.
Publicado: (2011)

Molecular recognition of RhlB and RNase D in the Caulobacter crescentus RNA degradosome
por: Voss, Jarrod E., et al.
Publicado: (2014)

Duplex structural differences and not 2′-hydroxyls explain the more stable binding of HIV-reverse transcriptase to RNA-DNA versus DNA-DNA
por: Olimpo, Jeffrey T., et al.
Publicado: (2010)

Downstream element determines RNase Y cleavage of the saePQRS operon in Staphylococcus aureus
por: Marincola, Gabriella, et al.
Publicado: (2017)

Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′,3′-dideoxyguanosine-5′-triphosphates as adenosine analogs
por: Herman, Brian D., et al.
Publicado: (2012)

Asymmetric conformational maturation of HIV-1 reverse transcriptase
por: Zheng, Xunhai, et al.
Publicado: (2015)

Unique subunit packing in mycobacterial nanoRNase leads to alternate substrate recognitions in DHH phosphodiesterases
por: Srivastav, Rajpal, et al.
Publicado: (2014)

Direct entry by RNase E is a major pathway for the degradation and processing of RNA in Escherichia coli
por: Clarke, Justin E., et al.
Publicado: (2014)

Substrate recognition and cleavage-site selection by a single-subunit protein-only RNase P
por: Brillante, Nadia, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_vpgp2hibsc999g50fqunhf08m5