New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone

A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the...

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Detalles Bibliográficos
Autores principales: Voon, Hsiao P.J., Wong, Lee H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Survey and Summary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770241/
https://www.ncbi.nlm.nih.gov/pubmed/26773061
http://dx.doi.org/10.1093/nar/gkw012
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author Voon, Hsiao P.J.
Wong, Lee H.
author_facet Voon, Hsiao P.J.
Wong, Lee H.
author_sort Voon, Hsiao P.J.
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description A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
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spelling pubmed-47702412016-02-29 New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone Voon, Hsiao P.J. Wong, Lee H. Nucleic Acids Res Survey and Summary A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome. Oxford University Press 2016-02-29 2016-01-14 /pmc/articles/PMC4770241/ /pubmed/26773061 http://dx.doi.org/10.1093/nar/gkw012 Text en © The Author(s) 2016. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Survey and Summary
Voon, Hsiao P.J.
Wong, Lee H.
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title_full New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title_fullStr New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title_full_unstemmed New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title_short New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
title_sort new players in heterochromatin silencing: histone variant h3.3 and the atrx/daxx chaperone
topic Survey and Summary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770241/
https://www.ncbi.nlm.nih.gov/pubmed/26773061
http://dx.doi.org/10.1093/nar/gkw012
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