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Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology
Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain. Aβ plaques are produced through sequential β/γ cleavage of amyloid precursor protein (APP), of which there are three main APP isoforms: APP(695), APP(751) and APP(770.) KPI-APPs (APP(751) and APP(770)) are known to...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770288/ https://www.ncbi.nlm.nih.gov/pubmed/26924205 http://dx.doi.org/10.1038/srep22244 |