Lost region in amyloid precursor protein (APP) through TALEN-mediated genome editing alters mitochondrial morphology

Alzheimer’s disease (AD) is characterized by amyloid-β (Aβ) deposition in the brain. Aβ plaques are produced through sequential β/γ cleavage of amyloid precursor protein (APP), of which there are three main APP isoforms: APP(695), APP(751) and APP(770.) KPI-APPs (APP(751) and APP(770)) are known to...

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Detalles Bibliográficos
Autores principales: Wang, Yajie, Wu, Fengyi, Pan, Haining, Zheng, Wenzhong, Feng, Chi, Wang, Yunfu, Deng, Zixin, Wang, Lianrong, Luo, Jie, Chen, Shi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770288/
https://www.ncbi.nlm.nih.gov/pubmed/26924205
http://dx.doi.org/10.1038/srep22244

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