(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA‐Catalyzed GTP Hydrolysis

Molecular details for RhoA/GAP catalysis of the hydrolysis of GTP to GDP are poorly understood. We use (19)F NMR chemical shifts in the MgF(3) (−) transition state analogue (TSA) complex as a spectroscopic reporter to indicate electron distribution for the γ‐PO(3) (−) oxygens in the corresponding TS...

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Detalles Bibliográficos
Autores principales: Jin, Yi, Molt, Robert W., Waltho, Jonathan P., Richards, Nigel G. J., Blackburn, G. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770445/
https://www.ncbi.nlm.nih.gov/pubmed/26822702
http://dx.doi.org/10.1002/anie.201509477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770445/
https://www.ncbi.nlm.nih.gov/pubmed/26822702
http://dx.doi.org/10.1002/anie.201509477

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