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(19)F NMR and DFT Analysis Reveal Structural and Electronic Transition State Features for RhoA‐Catalyzed GTP Hydrolysis
Molecular details for RhoA/GAP catalysis of the hydrolysis of GTP to GDP are poorly understood. We use (19)F NMR chemical shifts in the MgF(3) (−) transition state analogue (TSA) complex as a spectroscopic reporter to indicate electron distribution for the γ‐PO(3) (−) oxygens in the corresponding TS...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770445/ https://www.ncbi.nlm.nih.gov/pubmed/26822702 http://dx.doi.org/10.1002/anie.201509477 |