“Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”

Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here, we generate genome-wide maps of crossovers and chromosome segregation patterns by recov...

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Detalles Bibliográficos
Autores principales: Ottolini, Christian S., Newnham, Louise, Capalbo, Antonio, Natesan, Senthilkumar A., Joshi, Hrishikesh A., Cimadomo, Danilo, Griffin, Darren K., Sage, Karen, Summers, Michael C., Thornhill, Alan R., Housworth, Elizabeth, Herbert, Alex D., Rienzi, Laura, Ubaldi, Filippo M., Handyside, Alan H., Hoffmann, Eva R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770575/
https://www.ncbi.nlm.nih.gov/pubmed/25985139
http://dx.doi.org/10.1038/ng.3306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770575/
https://www.ncbi.nlm.nih.gov/pubmed/25985139
http://dx.doi.org/10.1038/ng.3306

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