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“Genome-wide recombination and chromosome segregation in human oocytes and embryos reveal selection for maternal recombination rates”
Crossover recombination reshuffles genes and prevents errors in segregation that lead to extra or missing chromosomes (aneuploidy) in human eggs, a major cause of pregnancy failure and congenital disorders. Here, we generate genome-wide maps of crossovers and chromosome segregation patterns by recov...
Autores principales: | Ottolini, Christian S., Newnham, Louise, Capalbo, Antonio, Natesan, Senthilkumar A., Joshi, Hrishikesh A., Cimadomo, Danilo, Griffin, Darren K., Sage, Karen, Summers, Michael C., Thornhill, Alan R., Housworth, Elizabeth, Herbert, Alex D., Rienzi, Laura, Ubaldi, Filippo M., Handyside, Alan H., Hoffmann, Eva R. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770575/ https://www.ncbi.nlm.nih.gov/pubmed/25985139 http://dx.doi.org/10.1038/ng.3306 |
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