MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation

The G(2) DNA damage checkpoint is one of the most important mechanisms controlling G(2)–mitosis transition. The kinase Greatwall (MASTL in human) promotes normal G(2)–mitosis transition by inhibiting PP2A via ARPP19 and ENSA. In this study, we demonstrate that MASTL is critical for maintaining genom...

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Detalles Bibliográficos
Autores principales: Wong, Po Yee, Ma, Hoi Tang, Lee, Hyun-jung, Poon, Randy Y. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770598/
https://www.ncbi.nlm.nih.gov/pubmed/26923777
http://dx.doi.org/10.1038/srep22230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770598/
https://www.ncbi.nlm.nih.gov/pubmed/26923777
http://dx.doi.org/10.1038/srep22230

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