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MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation
The G(2) DNA damage checkpoint is one of the most important mechanisms controlling G(2)–mitosis transition. The kinase Greatwall (MASTL in human) promotes normal G(2)–mitosis transition by inhibiting PP2A via ARPP19 and ENSA. In this study, we demonstrate that MASTL is critical for maintaining genom...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770598/ https://www.ncbi.nlm.nih.gov/pubmed/26923777 http://dx.doi.org/10.1038/srep22230 |