Prognostic impact of mismatch repair genes germline defects in colorectal cancer patients: are all mutations equal?

BACKGROUND: Lynch syndrome (LS) is the most common hereditary colorectal cancer (CRC) syndrome, caused by germline mutations in MisMatch Repair (MMR) genes, particularly in MLH1, MSH2 and MSH6. Patients with LS seem to have a more favourable prognosis than those with sporadic CRC, although the progn...

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Detalles Bibliográficos
Autores principales: Maccaroni, Elena, Bracci, Raffaella, Giampieri, Riccardo, Bianchi, Francesca, Belvederesi, Laura, Brugiati, Cristiana, Pagliaretta, Silvia, Del Prete, Michela, Scartozzi, Mario, Cascinu, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770733/
https://www.ncbi.nlm.nih.gov/pubmed/26485756

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770733/
https://www.ncbi.nlm.nih.gov/pubmed/26485756

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