Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma/pheochromocytoma and smooth muscle tumors

Succinate dehydrogenase (SDH) and fumarate hydratase (FH) are tricarboxylic acid (TCA) cycle enzymes and tumor suppressors. Loss-of-function mutations give rise to hereditary paragangliomas/pheochromocytomas and hereditary leiomyomatosis and renal cell carcinoma. Inactivation of SDH and FH results i...

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Detalles Bibliográficos
Autores principales: Hoekstra, Attje S., de Graaff, Marieke A., Briaire-de Bruijn, Inge H., Ras, Cor, Seifar, Reza Maleki, van Minderhout, Ivonne, Cornelisse, Cees J., Hogendoorn, Pancras C.W., Breuning, Martijn H., Suijker, Johnny, Korpershoek, Esther, Kunst, Henricus P.M., Frizzell, Norma, Devilee, Peter, Bayley, Jean-Pierre, Bovée, Judith V.M.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770736/
https://www.ncbi.nlm.nih.gov/pubmed/26472283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770736/
https://www.ncbi.nlm.nih.gov/pubmed/26472283

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