Cargando…
OX130 Monoclonal Antibody Recognizes Human SIRPβ1 but Cross-Reacts on SIRPα from One Allele
The SIRP family of myeloid-paired receptors are characterized by having both activating and inhibiting members with extracellular regions that are relatively similar. Making good reagents to these receptors is not straightforward, particularly as they are relatively polymorphic. We describe the prod...
Autores principales: | Hatherley, Deborah, Aknin, Marie-Laure, Barclay, Neil |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Mary Ann Liebert, Inc.
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4770912/ https://www.ncbi.nlm.nih.gov/pubmed/26871367 http://dx.doi.org/10.1089/mab.2015.0054 |
Ejemplares similares
-
Targeting SIRPα in cancer
por: Ho, Jenny M., et al.
Publicado: (2013) -
Crystal structure of signal regulatory protein gamma (SIRPγ) in complex with an antibody Fab fragment
por: Nettleship, Joanne E, et al.
Publicado: (2013) -
Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint
por: Voets, Erik, et al.
Publicado: (2019) -
Anticancer efficacy of monotherapy with antibodies to SIRPα/SIRPβ1 mediated by induction of antitumorigenic macrophages
por: Sakamoto, Mariko, et al.
Publicado: (2021) -
BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells
por: van Helden, Mary J, et al.
Publicado: (2023)