Hydrophobic Core Variations Provide a Structural Framework for Tyrosine Kinase Evolution and Functional Specialization

Protein tyrosine kinases (PTKs) are a group of closely related enzymes that have evolutionarily diverged from serine/threonine kinases (STKs) to regulate pathways associated with multi-cellularity. Evolutionary divergence of PTKs from STKs has occurred through accumulation of mutations in the active...

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Detalles Bibliográficos
Autores principales: Mohanty, Smita, Oruganty, Krishnadev, Kwon, Annie, Byrne, Dominic P., Ferries, Samantha, Ruan, Zheng, Hanold, Laura E., Katiyar, Samiksha, Kennedy, Eileen J., Eyers, Patrick A., Kannan, Natarajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771162/
https://www.ncbi.nlm.nih.gov/pubmed/26925779
http://dx.doi.org/10.1371/journal.pgen.1005885

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771162/
https://www.ncbi.nlm.nih.gov/pubmed/26925779
http://dx.doi.org/10.1371/journal.pgen.1005885

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