Acquired EGFR C797S mediates resistance to AZD9291 in advanced non-small cell lung cancer harboring EGFR T790M

Here we studied cell-free plasma DNA (cfDNA) collected from subjects with advanced lung cancer whose tumors had developed resistance to the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) AZD9291. We first performed next-generation sequencing of cfDNA from seven subjects and...

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Detalles Bibliográficos
Autores principales: Thress, Kenneth S., Paweletz, Cloud P., Felip, Enriqueta, Cho, Byoung Chul, Stetson, Daniel, Dougherty, Brian, Lai, Zhongwu, Markovets, Aleksandra, Vivancos, Ana, Kuang, Yanan, Ercan, Dalia, Matthews, Sarah, Cantarini, Mireille, Barrett, J. Carl, Jänne, Pasi A., Oxnard, Geoffrey R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771182/
https://www.ncbi.nlm.nih.gov/pubmed/25939061
http://dx.doi.org/10.1038/nm.3854

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771182/
https://www.ncbi.nlm.nih.gov/pubmed/25939061
http://dx.doi.org/10.1038/nm.3854

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