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Feedbacks, Bifurcations, and Cell Fate Decision-Making in the p53 System
The p53 transcription factor is a regulator of key cellular processes including DNA repair, cell cycle arrest, and apoptosis. In this theoretical study, we investigate how the complex circuitry of the p53 network allows for stochastic yet unambiguous cell fate decision-making. The proposed Markov ch...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771203/ https://www.ncbi.nlm.nih.gov/pubmed/26928575 http://dx.doi.org/10.1371/journal.pcbi.1004787 |