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Oligomers of Heat-Shock Proteins: Structures That Don’t Imply Function

Most proteins must remain soluble in the cytosol in order to perform their biological functions. To protect against undesired protein aggregation, living cells maintain a population of molecular chaperones that ensure the solubility of the proteome. Here we report simulations of a lattice model of i...

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Detalles Bibliográficos
Autores principales: Jacobs, William M., Knowles, Tuomas P. J., Frenkel, Daan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4771702/
https://www.ncbi.nlm.nih.gov/pubmed/26928170
http://dx.doi.org/10.1371/journal.pcbi.1004756