Cargando…

The hGFAP-driven conditional TSPO knockout is protective in a mouse model of multiple sclerosis

The mitochondrial translocator protein (TSPO) has been implicated in CNS diseases. Here, we sought to determine the specific role of TSPO in experimental autoimmune encephalomyelitis (EAE), the most studied animal model of multiple sclerosis (MS). To fundamentally elucidate the functions of TSPO, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daugherty, Daniel J., Chechneva, Olga, Mayrhofer, Florian, Deng, Wenbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772008/ https://www.ncbi.nlm.nih.gov/pubmed/26925573 http://dx.doi.org/10.1038/srep22556

Ejemplares similares

A TSPO ligand is protective in a mouse model of multiple sclerosis
por: Daugherty, Daniel J, et al.
Publicado: (2013)

Mitochondrial translocator protein (TSPO), astrocytes and neuroinflammation
por: Chechneva, Olga V., et al.
Publicado: (2016)

Germ-Line Recombination Activity of the Widely Used hGFAP-Cre and Nestin-Cre Transgenes
por: Zhang, Jiong, et al.
Publicado: (2013)

Astrocyte Specificity and Coverage of hGFAP-CreERT2 [Tg(GFAP-Cre/ERT2)13Kdmc] Mouse Line in Various Brain Regions
por: Park, Yongmin Mason, et al.
Publicado: (2018)

hGFAP-mediated GLI2 overexpression leads to early death and severe cerebellar malformations with rare tumor formation
por: Niesen, Judith, et al.
Publicado: (2023)

Characterization of pancreatic glucagon-producing tumors and pituitary gland tumors in transgenic mice overexpressing MYCN in hGFAP-positive cells
por: Fielitz, Kathrin, et al.
Publicado: (2016)

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro
por: Namchaiw, Poommaree, et al.
Publicado: (2019)

Transfer of nuclear and ribosomal material from Sox10-lineage cells to neurons in the mouse brain
por: Mayrhofer, Florian, et al.
Publicado: (2023)

The Comprehensive Steroidome in Complete TSPO/PBR Knockout Mice under Basal Conditions
por: Liere, Philippe, et al.
Publicado: (2023)

Amhr2-Cre–Mediated Global Tspo Knockout
por: Fan, Jinjiang, et al.
Publicado: (2020)

Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice
por: Kriszta, Gábor, et al.
Publicado: (2019)

Commentary: Amhr2-Cre-Mediated Global Tspo Knockout
por: Selvaraj, Vimal, et al.
Publicado: (2020)

Empowering sonic hedgehog to rescue brain cells after ischemic stroke
por: Chechneva, Olga V., et al.
Publicado: (2015)

A Smoothened receptor agonist is neuroprotective and promotes regeneration after ischemic brain injury
por: Chechneva, O V, et al.
Publicado: (2014)

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
por: Banati, Richard B., et al.
Publicado: (2014)

Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure
por: Thai, Phung N., et al.
Publicado: (2018)

Imaging neuroinflammation in multiple sclerosis using TSPO-PET
por: Airas, Laura, et al.
Publicado: (2015)

Longitudinal change in TSPO PET imaging in progressive multiple sclerosis
por: Kang, Yeona, et al.
Publicado: (2021)

Ectopic insert-dependent neuronal expression of GFAP promoter-driven AAV constructs in adult mouse retina
por: Le, Nguyet, et al.
Publicado: (2022)

Serum GFAP as a biomarker for disease severity in multiple sclerosis
por: Abdelhak, A., et al.
Publicado: (2018)

GFAP at 50
por: Messing, Albee, et al.
Publicado: (2020)

Neuroinflammation Is Associated with GFAP and sTREM2 Levels in Multiple Sclerosis
por: Azzolini, Federica, et al.
Publicado: (2022)

Astrocytic TSPO Upregulation Appears Before Microglial TSPO in Alzheimer’s Disease
por: Tournier, Benjamin B., et al.
Publicado: (2020)

Deletion of TSPO Causes Dysregulation of Cholesterol Metabolism in Mouse Retina
por: Farhan, Fahad, et al.
Publicado: (2021)

GFAPδ Expression in Glia of the Developmental and Adolescent Mouse Brain
por: Mamber, Carlyn, et al.
Publicado: (2012)

TSPO-Detectable Chronic Active Lesions Predict Disease Progression in Multiple Sclerosis
por: Polvinen, Eero, et al.
Publicado: (2023)

TSPO expression in brain tumours: is TSPO a target for brain tumour imaging?
por: Roncaroli, Federico, et al.
Publicado: (2016)

Author Correction: Serum GFAP as a biomarker for disease severity in multiple sclerosis
por: Abdelhak, A., et al.
Publicado: (2019)

Regulation of GFAP Expression
por: Brenner, Michael, et al.
Publicado: (2021)

Characterization of an Osmr Conditional Knockout Mouse Model
por: Schwartz, Logan S., et al.
Publicado: (2023)

CRISPR-Cas9 Mediated TSPO Gene Knockout alters Respiration and Cellular Metabolism in Human Primary Microglia Cells
por: Milenkovic, Vladimir M., et al.
Publicado: (2019)

GFAP expression as an indicator of disease severity in mouse models of Alexander disease
por: Jany, Paige L., et al.
Publicado: (2013)

Brain TSPO-PET predicts later disease progression independent of relapses in multiple sclerosis
por: Sucksdorff, Marcus, et al.
Publicado: (2020)

Serum GFAP in multiple sclerosis: correlation with disease type and MRI markers of disease severity
por: Ayrignac, Xavier, et al.
Publicado: (2020)

TSPO imaging in parkinsonian disorders
por: Gerhard, Alexander
Publicado: (2016)

Characterization of the High-Affinity Drug Ligand Binding Site of Mouse Recombinant TSPO
por: Iatmanen-Harbi, Soria, et al.
Publicado: (2019)

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis
por: Takahashi, Kazuya, et al.
Publicado: (2007)

Viral Vector-Based Dissection of Marmoset GFAP Promoter in Mouse and Marmoset Brains
por: Shinohara, Yoichiro, et al.
Publicado: (2016)

GFAP positivity in neurons following traumatic brain injuries
por: Zwirner, Johann, et al.
Publicado: (2021)

CSF and Blood Levels of GFAP in Alexander Disease
por: Jany, Paige L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_f47uv3j1upq9g8f0ppnoougjfa