TDP-43 or FUS-induced misfolded human wild-type SOD1 can propagate intercellularly in a prion-like fashion

Amyotrophic lateral sclerosis (ALS), which appears to spread through the neuroaxis in a spatiotemporally restricted manner, is linked to heritable mutations in genes encoding SOD1, TDP-43, FUS, C9ORF72, or can occur sporadically without recognized genetic mutations. Misfolded human wild-type (HuWt)...

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Detalles Bibliográficos
Autores principales: Pokrishevsky, Edward, Grad, Leslie I., Cashman, Neil R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772009/
https://www.ncbi.nlm.nih.gov/pubmed/26926802
http://dx.doi.org/10.1038/srep22155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772009/
https://www.ncbi.nlm.nih.gov/pubmed/26926802
http://dx.doi.org/10.1038/srep22155

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