Interaction with Pyruvate Kinase M2 Destabilizes Tristetraprolin by Proteasome Degradation and Regulates Cell Proliferation in Breast Cancer

Pyruvate kinase M2 (PKM2), which is predominantly expressed in most cancers, plays a key role in the Warburg effect. However, how PKM2 functions as a tumor supportive protein has not been fully elucidated. Here, we identified tristetraprolin (TTP), an AU-rich, element-binding protein that regulates...

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Detalles Bibliográficos
Autores principales: Huang, Liangqian, Yu, Zhenhai, Zhang, Zhenchao, Ma, Wenjing, Song, Shaoli, Huang, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772106/
https://www.ncbi.nlm.nih.gov/pubmed/26926077
http://dx.doi.org/10.1038/srep22449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772106/
https://www.ncbi.nlm.nih.gov/pubmed/26926077
http://dx.doi.org/10.1038/srep22449

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