Structural basis for the regulation of enzymatic activity of Regnase-1 by domain-domain interactions

Regnase-1 is an RNase that directly cleaves mRNAs of inflammatory genes such as IL-6 and IL-12p40, and negatively regulates cellular inflammatory responses. Here, we report the structures of four domains of Regnase-1 from Mus musculus—the N-terminal domain (NTD), PilT N-terminus like (PIN) domain, z...

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Detalles Bibliográficos
Autores principales: Yokogawa, Mariko, Tsushima, Takashi, Noda, Nobuo N., Kumeta, Hiroyuki, Enokizono, Yoshiaki, Yamashita, Kazuo, Standley, Daron M., Takeuchi, Osamu, Akira, Shizuo, Inagaki, Fuyuhiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772114/
https://www.ncbi.nlm.nih.gov/pubmed/26927947
http://dx.doi.org/10.1038/srep22324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772114/
https://www.ncbi.nlm.nih.gov/pubmed/26927947
http://dx.doi.org/10.1038/srep22324

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