Retigabine holds K(V)7 channels open and stabilizes the resting potential

The anticonvulsant Retigabine is a K(V)7 channel agonist used to treat hyperexcitability disorders in humans. Retigabine shifts the voltage dependence for activation of the heteromeric K(V)7.2/K(V)7.3 channel to more negative potentials, thus facilitating activation. Although the molecular mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales: Corbin-Leftwich, Aaron, Mossadeq, Sayeed M., Ha, Junghoon, Ruchala, Iwona, Le, Audrey Han Ngoc, Villalba-Galea, Carlos A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2016
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772374/
https://www.ncbi.nlm.nih.gov/pubmed/26880756
http://dx.doi.org/10.1085/jgp.201511517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772374/
https://www.ncbi.nlm.nih.gov/pubmed/26880756
http://dx.doi.org/10.1085/jgp.201511517

Ejemplares similares