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Retigabine holds K(V)7 channels open and stabilizes the resting potential

The anticonvulsant Retigabine is a K(V)7 channel agonist used to treat hyperexcitability disorders in humans. Retigabine shifts the voltage dependence for activation of the heteromeric K(V)7.2/K(V)7.3 channel to more negative potentials, thus facilitating activation. Although the molecular mechanism...

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Detalles Bibliográficos
Autores principales:	Corbin-Leftwich, Aaron, Mossadeq, Sayeed M., Ha, Junghoon, Ruchala, Iwona, Le, Audrey Han Ngoc, Villalba-Galea, Carlos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2016
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772374/ https://www.ncbi.nlm.nih.gov/pubmed/26880756 http://dx.doi.org/10.1085/jgp.201511517

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