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Ligand-dependent responses of the silkworm prothoracicotropic hormone receptor, Torso, are maintained by unusual intermolecular disulfide bridges in the transmembrane region

The insect membrane-protein, Torso, is a member of the receptor-tyrosine-kinase family, and is activated by its ligand, prothoracicotropic hormone (PTTH). Although PTTH is one of the most important regulators of insect development, the mechanism of Torso activation by the hormone has remained elusiv...

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Detalles Bibliográficos
Autores principales: Konogami, Tadafumi, Yang, Yiwen, Ogihara, Mari H., Hikiba, Juri, Kataoka, Hiroshi, Saito, Kazuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772477/
https://www.ncbi.nlm.nih.gov/pubmed/26928300
http://dx.doi.org/10.1038/srep22437