Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems

Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge of cellular subsystems. These subsystems and their hierarchical organizat...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Michael Ku, Kramer, Michael, Dutkowski, Janusz, Srivas, Rohith, Licon, Katherine, Kreisberg, Jason, Ng, Cherie T., Krogan, Nevan, Sharan, Roded, Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772745/
https://www.ncbi.nlm.nih.gov/pubmed/26949740
http://dx.doi.org/10.1016/j.cels.2016.02.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772745/
https://www.ncbi.nlm.nih.gov/pubmed/26949740
http://dx.doi.org/10.1016/j.cels.2016.02.003

Ejemplares similares