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Translation of Genotype to Phenotype by a Hierarchy of Cell Subsystems
Accurately translating genotype to phenotype requires accounting for the functional impact of genetic variation at many biological scales. Here we present a strategy for genotype-phenotype reasoning based on existing knowledge of cellular subsystems. These subsystems and their hierarchical organizat...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772745/ https://www.ncbi.nlm.nih.gov/pubmed/26949740 http://dx.doi.org/10.1016/j.cels.2016.02.003 |