The Antiviral Activity of Approved and Novel Drugs against HIV-1 Mutations Evaluated under the Consideration of Dose-Response Curve Slope

OBJECTIVES: This study was designed to identify common HIV-1 mutation complexes affecting the slope of inhibition curve, and to propose a new parameter incorporating both the IC50 and the slope to evaluate phenotypic resistance. METHODS: Utilizing site-directed mutagenesis, we constructed 22 HIV-1 c...

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Detalles Bibliográficos
Autores principales: Chang, Shuai, Zhuang, Daomin, Guo, Wei, Li, Lin, Zhang, Wenfu, Liu, Siyang, Li, Hanping, Liu, Yongjian, Bao, Zuoyi, Han, Jingwan, Song, Hongbin, Li, Jingyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773073/
https://www.ncbi.nlm.nih.gov/pubmed/26930645
http://dx.doi.org/10.1371/journal.pone.0149467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773073/
https://www.ncbi.nlm.nih.gov/pubmed/26930645
http://dx.doi.org/10.1371/journal.pone.0149467

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