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Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip

Neurovascular inflammation is a major contributor to many neurological disorders, but modeling these processes in vitro has proven to be difficult. Here, we microengineered a three-dimensional (3D) model of the human blood-brain barrier (BBB) within a microfluidic chip by creating a cylindrical coll...

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Detalles Bibliográficos
Autores principales: Herland, Anna, van der Meer, Andries D., FitzGerald, Edward A., Park, Tae-Eun, Sleeboom, Jelle J. F., Ingber, Donald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773137/
https://www.ncbi.nlm.nih.gov/pubmed/26930059
http://dx.doi.org/10.1371/journal.pone.0150360