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TLR4 Activation Promotes Bone Marrow MSC Proliferation and Osteogenic Differentiation via Wnt3a and Wnt5a Signaling

Mesenchymal stem cells (MSCs) from adult bone marrow maintain their self-renewal ability and the ability to differentiate into osteoblast. Thus, adult bone marrow MSCs play a key role in the regeneration of bone tissue. Previous studies indicated that TLR4 is expressed in MSCs and is critical in reg...

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Detalles Bibliográficos
Autores principales: He, Xiaoqing, Wang, Hai, Jin, Tao, Xu, Yongqing, Mei, Liangbin, Yang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773221/
https://www.ncbi.nlm.nih.gov/pubmed/26930594
http://dx.doi.org/10.1371/journal.pone.0149876