Population physiologically-based pharmacokinetic model incorporating lymphatic uptake for a subcutaneously administered pegylated peptide

PURPOSE: Physiologically-based pharmacokinetic (PBPK) models provide a rational mechanistic approach for predicting the time course of macromolecules in plasma. Population PBPK models for large molecules necessitate incorporation of lymphatic circulation to mechanistically account for biodistributio...

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Detalles Bibliográficos
Autores principales: Offman, Elliot, Phipps, Colin, Edginton, Andrea N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773320/
https://www.ncbi.nlm.nih.gov/pubmed/26932471
http://dx.doi.org/10.1186/s40203-016-0018-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773320/
https://www.ncbi.nlm.nih.gov/pubmed/26932471
http://dx.doi.org/10.1186/s40203-016-0018-5

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