Drug design from the cryptic inhibitor envelope

Conformational dynamics plays an important role in enzyme catalysis, allosteric regulation of protein functions and assembly of macromolecular complexes. Despite these well-established roles, such information has yet to be exploited for drug design. Here we show by nuclear magnetic resonance spectro...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Chul-Jin, Liang, Xiaofei, Wu, Qinglin, Najeeb, Javaria, Zhao, Jinshi, Gopalaswamy, Ramesh, Titecat, Marie, Sebbane, Florent, Lemaitre, Nadine, Toone, Eric J., Zhou, Pei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773385/
https://www.ncbi.nlm.nih.gov/pubmed/26912110
http://dx.doi.org/10.1038/ncomms10638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773385/
https://www.ncbi.nlm.nih.gov/pubmed/26912110
http://dx.doi.org/10.1038/ncomms10638

Ejemplares similares