The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

The spindle checkpoint senses unattached kinetochores and inhibits the Cdc20-bound anaphase-promoting complex or cyclosome (APC/C), to delay anaphase, thereby preventing aneuploidy. A critical checkpoint inhibitor of APC/C(Cdc20) is the mitotic checkpoint complex (MCC). It is unclear whether MCC suf...

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Detalles Bibliográficos
Autores principales: Jia, Luying, Li, Bing, Yu, Hongtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773433/
https://www.ncbi.nlm.nih.gov/pubmed/26912231
http://dx.doi.org/10.1038/ncomms10818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773433/
https://www.ncbi.nlm.nih.gov/pubmed/26912231
http://dx.doi.org/10.1038/ncomms10818

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