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Src regulates insulin secretion and glucose metabolism by influencing subcellular localization of glucokinase in pancreatic β‐cells

AIMS/INTRODUCTION: Src, a non‐receptor tyrosine kinase, regulates a wide range of cellular functions, and hyperactivity of Src is involved in impaired glucose metabolism in pancreatic β‐cells. However, the physiological role of Src in glucose metabolism in normal, unstressed β‐cells remains unclear....

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Detalles Bibliográficos
Autores principales: Sato, Hiroki, Nagashima, Kazuaki, Ogura, Masahito, Sato, Yuichi, Tahara, Yumiko, Ogura, Kasane, Yamano, Gen, Sugizaki, Kazu, Fujita, Naotaka, Tatsuoka, Hisato, Usui, Ryota, Mukai, Eri, Fujimoto, Shimpei, Inagaki, Nobuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773676/
https://www.ncbi.nlm.nih.gov/pubmed/27042268
http://dx.doi.org/10.1111/jdi.12407