Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

The sonic hedgehog (Shh) signaling pathway is a major regulator of cell differentiation, cell proliferation, and tissue polarity. Aberrant activation of the Shh pathway has been shown in a variety of human cancers, including, basal cell carcinoma, malignant gliomas, medulloblastoma, leukemias, and c...

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Detalles Bibliográficos
Autores principales: Rimkus, Tadas K., Carpenter, Richard L., Qasem, Shadi, Chan, Michael, Lo, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773745/
https://www.ncbi.nlm.nih.gov/pubmed/26891329
http://dx.doi.org/10.3390/cancers8020022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773745/
https://www.ncbi.nlm.nih.gov/pubmed/26891329
http://dx.doi.org/10.3390/cancers8020022

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