Small Molecule Inhibited Parathyroid Hormone Mediated cAMP Response by N–Terminal Peptide Binding

Ligand binding to certain classes of G protein coupled receptors (GPCRs) stimulates the rapid synthesis of cAMP through G protein. Human parathyroid hormone (PTH), a member of class B GPCRs, binds to its receptor via its N–terminal domain, thereby activating the pathway to this secondary messenger i...

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Detalles Bibliográficos
Autores principales: Kumar, Amit, Baumann, Monika, Balbach, Jochen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773758/
https://www.ncbi.nlm.nih.gov/pubmed/26932583
http://dx.doi.org/10.1038/srep22533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773758/
https://www.ncbi.nlm.nih.gov/pubmed/26932583
http://dx.doi.org/10.1038/srep22533

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