N-terminal domain of Bothrops asper Myotoxin II Enhances the Activity of Endothelin Converting Enzyme-1 and Neprilysin

Neprilysin (NEP) and endothelin converting enzyme-1 (ECE-1) are two enzymes that degrade amyloid beta in the brain. Currently there are no molecules to stimulate the activity of these enzymes. Here we report, the discovery and characterisation of a peptide referred to as K49-P1-20, from the venom of...

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Detalles Bibliográficos
Autores principales: Smith, A. Ian, Rajapakse, Niwanthi W., Kleifeld, Oded, Lomonte, Bruno, Sikanyika, Nkumbu L., Spicer, Alexander J., Hodgson, Wayne C., Conroy, Paul J., Small, David H., Kaye, David M., Parkington, Helena C., Whisstock, James C., Kuruppu, Sanjaya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773759/
https://www.ncbi.nlm.nih.gov/pubmed/26931059
http://dx.doi.org/10.1038/srep22413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773759/
https://www.ncbi.nlm.nih.gov/pubmed/26931059
http://dx.doi.org/10.1038/srep22413

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