A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

A novel dinuclear Ir(III) complex 5 was discovered to be specific to G-quadruplex DNA, and was utilized in a label-free G-quadruplex-based detection platform for transcription factor activity. The principle of this assay was demonstrated by using HIF-1α as a model protein. Moreover, this HIF-1α dete...

Descripción completa

Detalles Bibliográficos
Autores principales: Lu, Lihua, Wang, Modi, Mao, Zhifeng, Kang, Tian-Shu, Chen, Xiu-Ping, Lu, Jin-Jian, Leung, Chung-Hang, Ma, Dik-Lung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773817/
https://www.ncbi.nlm.nih.gov/pubmed/26932240
http://dx.doi.org/10.1038/srep22458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773817/
https://www.ncbi.nlm.nih.gov/pubmed/26932240
http://dx.doi.org/10.1038/srep22458

Ejemplares similares