Pharmacoproteomic analysis reveals that metapristone (RU486 metabolite) intervenes E-cadherin and vimentin to realize cancer metastasis chemoprevention

Metapristone is the most predominant biological active metabolite of mifepristone, and being developed as a novel cancer metastasis chemopreventive agent by us. Despite its prominent metastasis chemopreventive effect, the underlying mechanism remains elusive. Our study, for the first time, demonstra...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Suhong, Yan, Cuicui, Yang, Xingtian, He, Sudang, Liu, Jian, Qin, Chongtao, Huang, Chuanzhong, Lu, Yusheng, Tian, Zhongping, Jia, Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773818/
https://www.ncbi.nlm.nih.gov/pubmed/26932781
http://dx.doi.org/10.1038/srep22388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773818/
https://www.ncbi.nlm.nih.gov/pubmed/26932781
http://dx.doi.org/10.1038/srep22388

Ejemplares similares