Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, a...

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Detalles Bibliográficos
Autores principales: Bratic, Ana, Kauppila, Timo E. S., Macao, Bertil, Grönke, Sebastian, Siibak, Triinu, Stewart, James B., Baggio, Francesca, Dols, Jacqueline, Partridge, Linda, Falkenberg, Maria, Wredenberg, Anna, Larsson, Nils-Göran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773887/
https://www.ncbi.nlm.nih.gov/pubmed/26554610
http://dx.doi.org/10.1038/ncomms9808

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773887/
https://www.ncbi.nlm.nih.gov/pubmed/26554610
http://dx.doi.org/10.1038/ncomms9808

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