Cargando…

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies

Replication errors are the main cause of mitochondrial DNA (mtDNA) mutations and a compelling approach to decrease mutation levels would therefore be to increase the fidelity of the catalytic subunit (POLγA) of the mtDNA polymerase. Here we genomically engineer the tamas locus, encoding fly POLγA, a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bratic, Ana, Kauppila, Timo E. S., Macao, Bertil, Grönke, Sebastian, Siibak, Triinu, Stewart, James B., Baggio, Francesca, Dols, Jacqueline, Partridge, Linda, Falkenberg, Maria, Wredenberg, Anna, Larsson, Nils-Göran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773887/ https://www.ncbi.nlm.nih.gov/pubmed/26554610 http://dx.doi.org/10.1038/ncomms9808

Ejemplares similares

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication
por: Macao, Bertil, et al.
Publicado: (2015)

A multi-systemic mitochondrial disorder due to a dominant p.Y955H disease variant in DNA polymerase gamma
por: Siibak, Triinu, et al.
Publicado: (2017)

Mutations of mitochondrial DNA are not major contributors to aging of fruit flies
por: Kauppila, Timo E. S., et al.
Publicado: (2018)

Switching between polymerase and exonuclease sites in DNA polymerase ε
por: Ganai, Rais A., et al.
Publicado: (2015)

Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation
por: Baggio, Francesca, et al.
Publicado: (2014)

The Bicoid Stability Factor Controls Polyadenylation and Expression of Specific Mitochondrial mRNAs in Drosophila melanogaster
por: Bratic, Ana, et al.
Publicado: (2011)

Noncanonical prokaryotic X family DNA polymerases lack polymerase activity and act as exonucleases
por: Prostova, Maria, et al.
Publicado: (2022)

Reduced structural flexibility for an exonuclease deficient DNA polymerase III mutant†
por: Gahlon, Hailey L., et al.
Publicado: (2018)

Polymerase and Exonuclease Activities in Herpes Simplex Virus Type 1 DNA Polymerase Are Not Highly Coordinated
por: Vashishtha, Ashwani Kumar, et al.
Publicado: (2014)

DNA polymerase ɛ and δ exonuclease domain mutations in endometrial cancer
por: Church, David N., et al.
Publicado: (2013)

Evolution of DNA polymerases: an inactivated polymerase-exonuclease module in Pol ε and a chimeric origin of eukaryotic polymerases from two classes of archaeal ancestors
por: Tahirov, Tahir H, et al.
Publicado: (2009)

Trypanosoma brucei Mitochondrial DNA Polymerase POLIB Contains a Novel Polymerase Domain Insertion That Confers Dominant Exonuclease Activity
por: Delzell, Stephanie B., et al.
Publicado: (2022)

MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals
por: Wredenberg, Anna, et al.
Publicado: (2013)

The proofreading exonuclease subunit ε of Escherichia coli DNA polymerase III is tethered to the polymerase subunit α via a flexible linker
por: Ozawa, Kiyoshi, et al.
Publicado: (2008)

Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2004)

Nucleoside alpha-thiotriphosphates, polymerases and the exonuclease III analysis of oligonucleotides containing phosphorothioate linkages
por: Yang, Zunyi, et al.
Publicado: (2007)

Exonuclease processivity of archaeal replicative DNA polymerase in association with PCNA is expedited by mismatches in DNA
por: Yoda, Takuya, et al.
Publicado: (2017)

Efficacious Preclinical Repurposing of the Nucleoside Analogue Didanosine against COVID-19 Polymerase and Exonuclease
por: Rabie, Amgad M.
Publicado: (2022)

Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer
por: Tian, Wenjuan, et al.
Publicado: (2022)

Correction: Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutations
por: Pavlov, Youri I, et al.
Publicado: (2007)

Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
por: Shinbrot, Eve, et al.
Publicado: (2014)

Inorganic phosphate, arsenate, and vanadate enhance exonuclease transcript cleavage by RNA polymerase by 2000-fold
por: Gottesman, Max E., et al.
Publicado: (2018)

DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2021)

Correction to ‘DNA polymerase gamma mutations that impair holoenzyme stability cause catalytic subunit depletion’
por: Silva-Pinheiro, Pedro, et al.
Publicado: (2021)

Proofreading exonuclease activity of human DNA polymerase δ and its effects on lesion-bypass DNA synthesis
por: Fazlieva, Ruzaliya, et al.
Publicado: (2009)

The TREX2 3′→ 5′ Exonuclease Physically Interacts with DNA Polymerase δ and Increases Its Accuracy
por: Shevelev, Igor V., et al.
Publicado: (2002)

New insights into the coordination between the polymerization and 3′-5′ exonuclease activities in ϕ29 DNA polymerase
por: del Prado, Alicia, et al.
Publicado: (2019)

The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C)
por: Tsuda, Masataka, et al.
Publicado: (2017)

Kinetic Characterization of Exonuclease-Deficient Staphylococcus aureus PolC, a C-family Replicative DNA Polymerase
por: Lahiri, Indrajit, et al.
Publicado: (2013)

Exonuclease resistant 18S and 25S ribosomal RNA components in yeast are possibly newly transcribed by RNA polymerase II
por: Fleischmann, Jacob, et al.
Publicado: (2020)

Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks
por: Hernández-Tamayo, Rogelio, et al.
Publicado: (2019)

Combination of Antiviral Drugs to Inhibit SARS-CoV-2 Polymerase and Exonuclease as Potential COVID-19 Therapeutics
por: Wang, Xuanting, et al.
Publicado: (2021)

Clinicopathologic and protein markers distinguishing the “polymerase epsilon exonuclease” from the “copy number low” subtype of endometrial cancer
por: Kim, Kidong, et al.
Publicado: (2022)

Chemoprophylactic Assessment of Combined Intranasal SARS-CoV-2 Polymerase and Exonuclease Inhibition in Syrian Golden Hamsters
por: Gallardo-Toledo, Eduardo, et al.
Publicado: (2023)

A sensor complements the steric gate when DNA polymerase ϵ discriminates ribonucleotides
por: Parkash, Vimal, et al.
Publicado: (2023)

The exceptionally high rate of spontaneous mutations in the polymerase delta proofreading exonuclease-deficient Saccharomyces cerevisiae strain starved for adenine
por: Achilli, Alessandro, et al.
Publicado: (2004)

The 3′–5′ proofreading exonuclease of archaeal family-B DNA polymerase hinders the copying of template strand deaminated bases
por: Russell, Henry J., et al.
Publicado: (2009)

Significant contribution of the 3′→5′ exonuclease activity to the high fidelity of nucleotide incorporation catalyzed by human DNA polymerase ϵ
por: Zahurancik, Walter J., et al.
Publicado: (2014)

Mutant POLQ and POLZ/REV3L DNA polymerases may contribute to the favorable survival of patients with tumors with POLE mutations outside the exonuclease domain
por: Huang, Fangjin, et al.
Publicado: (2020)

Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria
por: Matic, Stanka, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cdk4f0aibgcvvu3u41v47f3nc4