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Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

BACKGROUND: Sustained, persistent firing (PF) of cortical pyramidal neurons following a short depolarization is a crucial cellular mechanism required for spatial and working memory. Pyramidal neurons in the superficial and deep layers of the medial and lateral entorhinal cortex (EC) display this pro...

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Detalles Bibliográficos
Autores principales: Gibon, Julien, Barker, Philip A., Séguéla, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774087/
https://www.ncbi.nlm.nih.gov/pubmed/26932787
http://dx.doi.org/10.1186/s13041-016-0203-9