Blockade of P-Glycoprotein Decreased the Disposition of Phenformin and Increased Plasma Lactate Level

This study aimed to investigate the in vivo relevance of P-glycoprotein (P-gp) in the pharmacokinetics and adverse effect of phenformin. To investigate the involvement of P-gp in the transport of phenformin, a bi-directional transport of phenformin was carried out in LLC-PK1 cells overexpressing P-g...

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Detalles Bibliográficos
Autores principales: Choi, Min-Koo, Song, Im-Sook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774502/
https://www.ncbi.nlm.nih.gov/pubmed/26797108
http://dx.doi.org/10.4062/biomolther.2015.087

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774502/
https://www.ncbi.nlm.nih.gov/pubmed/26797108
http://dx.doi.org/10.4062/biomolther.2015.087

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