Radiation enhances the therapeutic effect of Banoxantrone in hypoxic tumour cells with elevated levels of nitric oxide synthase

Banoxantrone (AQ4N) is a prototype hypoxia selective cytotoxin that is activated by haem containing reductases such as inducible nitric oxide synthase (iNOS). In the present study, we evaluate whether elevated levels of iNOS in human tumour cells will improve their sensitivity to AQ4N. Further, we e...

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Detalles Bibliográficos
Autores principales: MEHIBEL, MANAL, SINGH, SIMENDRA, COWEN, RACHEL L., WILLIAMS, KAYE J., STRATFORD, IAN J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774668/
https://www.ncbi.nlm.nih.gov/pubmed/26782976
http://dx.doi.org/10.3892/or.2016.4555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4774668/
https://www.ncbi.nlm.nih.gov/pubmed/26782976
http://dx.doi.org/10.3892/or.2016.4555

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