Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution

The Ras-superfamily GTPases are central controllers of cell proliferation and morphology. Ras signaling is mediated by a system of interacting molecules: upstream enzymes (GEF/GAP) regulate Ras’s ability to recruit multiple competing downstream effectors. We developed a multiplexed, multi-turnover a...

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Detalles Bibliográficos
Autores principales: Coyle, Scott M, Lim, Wendell A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775219/
https://www.ncbi.nlm.nih.gov/pubmed/26765565
http://dx.doi.org/10.7554/eLife.12435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775219/
https://www.ncbi.nlm.nih.gov/pubmed/26765565
http://dx.doi.org/10.7554/eLife.12435

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