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Mapping the functional versatility and fragility of Ras GTPase signaling circuits through in vitro network reconstitution
The Ras-superfamily GTPases are central controllers of cell proliferation and morphology. Ras signaling is mediated by a system of interacting molecules: upstream enzymes (GEF/GAP) regulate Ras’s ability to recruit multiple competing downstream effectors. We developed a multiplexed, multi-turnover a...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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eLife Sciences Publications, Ltd
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775219/ https://www.ncbi.nlm.nih.gov/pubmed/26765565 http://dx.doi.org/10.7554/eLife.12435 |