Safety, Immunogenicity, and Protective Efficacy of Intradermal Immunization with Aseptic, Purified, Cryopreserved Plasmodium falciparum Sporozoites in Volunteers under Chloroquine Prophylaxis: A Randomized Controlled Trial

Immunization of volunteers under chloroquine prophylaxis by bites of Plasmodium falciparum sporozoite (PfSPZ)–infected mosquitoes induces > 90% protection against controlled human malaria infection (CHMI). We studied intradermal immunization with cryopreserved, infectious PfSPZ in volunteers taki...

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Detalles Bibliográficos
Autores principales: Bastiaens, Guido J. H., van Meer, Maurits P. A., Scholzen, Anja, Obiero, Joshua M., Vatanshenassan, Mansoureh, van Grinsven, Tim, Kim Lee Sim, B., Billingsley, Peter F., James, Eric R., Gunasekera, Anusha, Bijker, Else M., van Gemert, Geert-Jan, van de Vegte-Bolmer, Marga, Graumans, Wouter, Hermsen, Cornelus C., de Mast, Quirijn, van der Ven, André J. A. M., Hoffman, Stephen L., Sauerwein, Robert W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775905/
https://www.ncbi.nlm.nih.gov/pubmed/26711509
http://dx.doi.org/10.4269/ajtmh.15-0621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775905/
https://www.ncbi.nlm.nih.gov/pubmed/26711509
http://dx.doi.org/10.4269/ajtmh.15-0621

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