Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

Imidazopyridazine compounds are potent, ATP-competitive inhibitors of calcium-dependent protein kinase 1 (CDPK1) and of Plasmodium falciparum parasite growth in vitro. Here, we show that these compounds can be divided into two classes depending on the nature of the aromatic linker between the core a...

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Detalles Bibliográficos
Autores principales: Green, Judith L., Moon, Robert W., Whalley, David, Bowyer, Paul W., Wallace, Claire, Rochani, Ankit, Nageshan, Rishi K., Howell, Steven A., Grainger, Munira, Jones, Hayley M., Ansell, Keith H., Chapman, Timothy M., Taylor, Debra L., Osborne, Simon A., Baker, David A., Tatu, Utpal, Holder, Anthony A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775997/
https://www.ncbi.nlm.nih.gov/pubmed/26711771
http://dx.doi.org/10.1128/AAC.01748-15

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4775997/
https://www.ncbi.nlm.nih.gov/pubmed/26711771
http://dx.doi.org/10.1128/AAC.01748-15

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