Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration

Selective motor neuron degeneration is a hallmark of amyotrophic lateral sclerosis (ALS). Around 10% of all cases present as familial ALS (FALS), while sporadic ALS (SALS) accounts for the remaining 90%. Diverse genetic mutations leading to FALS have been identified, but the underlying causes of SAL...

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Detalles Bibliográficos
Autores principales: Edens, Brittany M., Miller, Nimrod, Ma, Yong-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776126/
https://www.ncbi.nlm.nih.gov/pubmed/26973461
http://dx.doi.org/10.3389/fncel.2016.00044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776126/
https://www.ncbi.nlm.nih.gov/pubmed/26973461
http://dx.doi.org/10.3389/fncel.2016.00044

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