Membrane-proximal TRAIL species are incapable of inducing short circuit apoptosis signaling: Implications for drug development and basic cytokine biology

TRAIL continues to garner substantial interest as a recombinant cancer therapeutic while the native cytokine itself serves important tumor surveillance functions when expressed in membrane-anchored form on activated immune effector cells. We have recently developed the genetically stabilized TRAIL p...

Descripción completa

Detalles Bibliográficos
Autores principales: Tatzel, Katharina, Kuroki, Lindsay, Dmitriev, Igor, Kashentseva, Elena, Curiel, David T., Goedegebuure, S. Peter, Powell, Matthew A., Mutch, David G., Hawkins, William G., Spitzer, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776141/
https://www.ncbi.nlm.nih.gov/pubmed/26935795
http://dx.doi.org/10.1038/srep22661

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776141/
https://www.ncbi.nlm.nih.gov/pubmed/26935795
http://dx.doi.org/10.1038/srep22661

Ejemplares similares