Cargando…
Distinct phosphorylation sites on the ghrelin receptor, GHSR1a, establish a code that determines the functions of ß-arrestins
The growth hormone secretagogue receptor, GHSR1a, mediates the biological activities of ghrelin, which includes the secretion of growth hormone, as well as the stimulation of appetite, food intake and maintenance of energy homeostasis. Mapping phosphorylation sites on GHSR1a and knowledge of how the...
Autores principales: | Bouzo-Lorenzo, Monica, Santo-Zas, Icía, Lodeiro, Maria, Nogueiras, Rubén, Casanueva, Felipe F., Castro, Marian, Pazos, Yolanda, Tobin, Andrew B, Butcher, Adrian J., Camiña, Jesús P. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4776146/ https://www.ncbi.nlm.nih.gov/pubmed/26935831 http://dx.doi.org/10.1038/srep22495 |
Ejemplares similares
-
The SHP-1 protein tyrosine phosphatase negatively modulates Akt signaling in the ghrelin/GHSR1a system
por: Lodeiro, Maria, et al.
Publicado: (2011) -
MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation
por: Rouault, Alix A.J., et al.
Publicado: (2022) -
c-Src Regulates Akt Signaling in Response to Ghrelin via β-Arrestin Signaling-Independent and -Dependent Mechanisms
por: Lodeiro, Maria, et al.
Publicado: (2009) -
Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice
por: Peris-Sampedro, Fiona, et al.
Publicado: (2021) -
OR0303 Syndecans Enhance Ghrelin-Induced GHSR1a Signaling
por: Prins, Karina, et al.
Publicado: (2023)